To make things even worse, Nextstop—the travel site where Systrom had worked earlier—would soon be sold to Facebook, where Systrom had also been close to working years before. “I was like, Great, I missed the Twitter boat. I missed the Facebook boat,” he says.
Kevin Systrom (Vanity Fair) 
And I realized the world of business really separates into these two groups. The attackers are the entrepreneurs who are disrupting the status quo, trying to change the world, take the hill, anything is possible, and have nothing to lose in most cases. They’re driven by passion and the idea and intensity. Large organizations — and it’s true of Fortune 500s and it’s also true of governments and other large organizations — are defenders. These guys aren’t trying to pursue the art of the possible, how to maximize opportunity. They actually are trying to minimize the downside, and hedge risk. They’re trying to de-risk situations. Entrepreneurs can’t even think this way. It’s not even a concept they understand.
- Steve Case (NYT)